Application of the One Health Approach to Reduce Antimicrobial Resistance in Bovine Mastitis

Ghafouri, Farzad; Naserkheil, Masoumeh; Sadeghi, Mostafa; Miraei-Ashtiani, Seyed Reza; Kastelic, John P.; Barkema, Herman W.; Razban, Vahid; Shirali, Masoud

doi:10.22059/domesticsj.2025.401425.1217

	Application of the One Health Approach to Reduce Antimicrobial Resistance in Bovine Mastitis
علمی- ترویجی (حرفه‌ای) دامِستیک
دوره 25، شماره 3 - شماره پیاپی 34، آذر 1404، صفحه 6-12 اصل مقاله (767.45 K)
نوع مقاله: مقاله علمی- ترویجی
شناسه دیجیتال (DOI): 10.22059/domesticsj.2025.401425.1217
نویسندگان
Farzad Ghafouri¹^{، 2}؛ Masoumeh Naserkheil³؛ Mostafa Sadeghi^* ¹؛ Seyed Reza Miraei-Ashtiani¹؛ John P. Kastelic⁴؛ Herman W. Barkema⁴؛ Vahid Razban⁵؛ Masoud Shirali^* ⁵^{، 6}
¹Department of Animal Science, University College of Agriculture and Natural Resources, University of Tehran, Karaj 77871-31587, Iran
²Agri-Food and Biosciences Institute (AFBI), Hillsborough, BT26 6DR, Northern Ireland, UK.
³Animal Genetics and Breeding Division, Animal Science Research Institute of Iran, Agriculture Re-search, Education, and Extension Organization, Karaj 31466-18361, Iran
⁴Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada
⁵Agri-Food and Biosciences Institute (AFBI), Hillsborough, BT26 6DR, Northern Ireland, UK
⁶School of Biological Sciences, Queen’s University Belfast, Belfast, BT9 5AJ, Northern Ireland, UK.
چکیده
Bovine mastitis continues to be an important issue for the dairy sector, worsened by the increasing threat of antimicrobial resistance (AMR), which threatens animal welfare, public health, and environmental sustainability. This manuscript highlights bovine mastitis, particularly recent developments in diagnostic techniques and use of the One Health approach to address AMR in management of this disease. The One Health framework highlights the interdependence of human, animal, and environmental health, promoting collaboration among veterinarians, farmers, public health officials, and environmental and social scientists to formulate integrated strategies. Presently, mastitis treatment predominantly depends on antimicrobials; however, their widespread use (and abuse) has hastened the rise of resistant bacterial strains, complicating treatment and heightening public health risks through dissemination of antimicrobial residues and resistant pathogens via milk, meat, and environmental pathways. In this review, we emphasize mechanisms of AMR gene transfer and stress the necessity of selective antimicrobial use for clinical mastitis and dry cow therapy, as well as prevention of transmission and enhanced diagnostics. Economic and environmental repercussions of AMR are considerable, requiring coordinated efforts to monitor resistance trends, educate stakeholders, and eliminate non-therapeutic antimicrobial use in livestock. The One Health approach facilitates interdisciplinary collaboration that is crucial for sustainable mastitis control, prevention of zoonotic diseases, and protection of global food security. In summary, integration of advanced diagnostics, responsible antimicrobial stewardship, and the One Health framework is a promising route to alleviate challenges posed by mastitis and AMR. This comprehensive strategy is essential for safeguarding livestock productivity, human health, and environmental integrity, ultimately ensuring resilient and sustainable dairy production systems on a global scale.
کلیدواژه‌ها
Antimicrobial resistance؛ Dairy cattle؛ Mastitis؛ One Health؛ Strategies

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